Structural basis of odorant recognition by a human odorant receptor

C.B. Billesboelle#, C.A. de March#, W.J. van der Velden#, N. Ma, J. Tewari, C.L. del Torrent, L. Li, B. Faust, N. Vaidehi*, H. Matsunami*, A. Manglik*

Nature, 615 (7953), 2023

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Antagonistic interactions between odorants alter human odor perception

Y. Fukutani, M. Abe, H. Saito, R. Eguchi, T. Tazawa, C.A. de March, M. Yohda, H. Matsunami

Current Biology, 33 (11), 2023

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Genetic and functional odorant receptor variation in the Homo lineage

C.A. de March#*, H. Matsunami, M. Abe, M. Cobb, K.C. Hoover#* 

iScience, 26 (1), 2023

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Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli

K.W Zhu, S.D Burton, M.H Nagai, J.D Silverman, C.A de March, M. Wachowiak, H. Matsunami

Nature communications, 13 (1) 2022

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Sequence Co-evolution and Structure Stabilization Modulate Olfactory Receptors Expression

S. Ghosh#, C.A. de March#, S. Branciamore, S. Kaleem, H. Matsunami, N. Vaidehi

Biophysical Journal, 121 (5), 2022

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Interactions among key residues regulate mammalian odorant receptor trafficking

R. Xu, X. Cong, Q Zheng, L Xu, M.J Ni, C.A de March, H. Matsunami, J Golebiowski, M. Ma, Y. Yu

The FASEB Journal, 36 (7), 2022

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Large-Scale G Protein-Coupled Olfactory Receptor–Ligand Pairing

X. Cong, W. Ren, J. Pacalon, R. Xu, L. Xu, X. Li, C.A. de March, H. Matsunami, H. Yu, Y. Yu, J. Golebiowski

ACS Central Science, 8 (3), 2022

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Machine learning assisted approach for finding novel high activity agonists of human ectopic olfactory receptors

A. Jabeen, C.A. de March, H. Matsunami, S. Ranganathan

Int. J. Mol. Sci.; 2021

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Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures

C.A de March, W.B. Titlow, T. Sengoku, P. Breheny, H. Matsunami, T.S. McClintock

Mol Cell Neurosci., 104, 103469, 2020

 

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

K. Ikegami#, C.A. de March#, M.H. Nagai, S. Ghosh, M. Do, R. Sharma, E.S. Bruguera, Y.E. Lu, Y. Fukutani, N. Vaidehi, M. Yohda, H. Matsunami

PNAS, 117, 2020

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Concentration-dependent recruitment of mammalian odorant receptors

X.S. Hu, K. Ikegami, A. Vihani, K.W. Zhu, M. Zapata, C.A. de March, M. Do, N. Vaidya, G. Kucera, C. Bock, Y. Jiang, M. Yohda, H. Matsunami

eNeuro, 7, 2020

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Real-time in vitro monitoring of odorant receptor activation by odorant in vapor phase

C.A. de March*, Y. Fukutani, A. Vihani, H. Kida, H. Matsunami*

Jove, 146, e59446, 2019

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A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing

E.M. Jones, R. Jajoo, D. Cancilla, N.B. Lubock, J. Wang, M. Satyadi, R. Cheung, C.A. de March, J.S. Bloom, H. Matsunami and S. Kosuri

Cell Systems, 8 (3) 2019

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Mammalian class I odorant receptors exhibit a conserved vestibular binding pocket

C. Bushdid#, C.A. de March#, J. Topin, M. Do, H. Matsunami, J. Golebiowski

Cellular and Molecular Life Sciences, 76 (5), 2019

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Vapor detection and discrimination with a panel of odorant receptors

H. Kidaa, Y. Fukutania, J. Mainland, C.A. de March, A. Vihani, Y.R. Li, Q. Chi, L. Liu, M. Kameda, M. Yohda, H. Matsunami

Nature Communications, 9 (1) 2018

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Agonists of G Protein-Coupled Odorant Receptors are Predicted from Chemical Features

C. Bushdid#, C.A. de March#, S. Fiorucci, H. Matsunami, J. Golebiowski

The Journal of Physical Chemistry Letters, p2235-2240, 2018

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Odorant receptor 7D4 activation dynamics

C.A. de March#, J. Topin#, E. Bruguera, G. Novikov, K. Ikegami, H. Matsunami, J. Golebiowski

Angewandte chemie, 57, 4554, 2018

 

Structure-function relationships of olfactory and taste receptors

M. Behrens, L. Briand, C.A. de March, H. Matsunami, A. Yamashita, W. Meyerhof & S. Weyand

Chemical senses, 43 (2) p81-7, 2018

 

Numerical models and in vitro assays to study Odorant Receptors

C. Bushdid#, C.A. de March#, H. Matsunami, J. Golebiowski

Methods in Molecular Biology, 1820, 2018

 

Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP–PKA pathway

T. Tong, S. E. Ryu, Y.Min, C.A. de March, C. Bushdid, J. Golebiowski, C. Moon, T. Park

Scientific Reports, 7, 9471, 2017

 

Olfactory disturbances in aging with and without dementia: towards new diagnostic tools

A. Gros, V. Manera, C.A. de March, N. Guevara, A. Koenig, L. Friedman, P. Robert, J. Golebiowski, R. David

 Journal of Laryngology & Otology, 131 (7) p572-9 2017

 

Ces molécules qui nous mènent par le bout du nez : Le codage moléculaire de la perception des odeurs.

C. Bushdid, C.A. de March, J. Topin, S. Antonczak, M. Bensafi, J. Golebiowski

Actualité Chimique, 406 p21-31, 2016

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Responsiveness of G protein-coupled odorant receptor is partially attributed to the activation mechanism

Y. Yu#, C.A. de March#, M.J. Ni, K.A. Adipietro, J. Golebiowski, H. Matsunami, M. Ma

PNAS, 112 p 14966-14971, 2015

 

Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptor

C.A. de March#, Y. Yu#, K.A. Adipietro, M.J. Ni, H. Matsunami, M. Ma,  J. Golebiowski

JACS, 137 p 8611–8616, 2015

 

G protein-coupled odorant receptors: From sequence to structure

C.A. de March#, S.-K. Kim#, S. Antonczak, W.A. Goddard III, J. Golebiowski

Protein Science, 24 p 1543-1548, 2015

 

Structure Odour Relationship reviewed in the postgenomic era

C.A. de March, S. Ryu, G. Sicard, C. Moon, J. Golebiowski

Flavor and Fragrance Journal, 30 p 342-36, 2015

 

A Computational microscope focused on the sense of smell

C.A. de March, J. Golebiowski

Biochimie, 107 p 1-3, 2014

 

Discrimination between Olfactory Receptor agonists and non-agonists

J. Topin, C.A. de March, L. Charlier, C. Ronin, S. Antonczak, J. Golebiowski

Chemistry a European Journal, 20 (33) p 10227–10230, 2014

 

Structure-Odor Relationships of hemisynthetic b-santalol analogues

C. Delasalle, C.A.de March, U. Meierhenrich, H. Brevard, J. Golebiowski, N. Baldovini

Chemistry & Biodiversity, 11 (11) p 1843-60,  2014

 

Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges

I. Kufareva, V. Katritch, Participant of GPCR Dock 2013, R.C. Stevens, R. Abagyan

Structure, 22 (8), p1120-39, 2014

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Chap. 4. Molecular Modeling of Olfactory Receptors

L. Charlier, J. Topin, C.A. de March, P. Lai, C. Crasto, J. Golebiowski

“Olfactory Receptors”  Humana Press.Ed. 2013